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ADVANCED SYNTHETIC STRATEGIES
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ADVANCED SYNTHETIC STRATEGIES
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Academic year 2023/2024
- Course ID
- BIO0233
- Teacher
- Annamaria Deagostino (Lecturer)
- Year
- 2nd year
- Teaching period
- Annual
- Type
- Distinctive
- Credits/Recognition
- 6
- Course disciplinary sector (SSD)
- CHIM/06 - organic chemistry
- Delivery
- Formal authority
- Language
- English
- Attendance
- Optional
- Type of examination
- Oral
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Sommario del corso
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Course objectives
The goal of the course is to describe tha main synthetic protocols available for the conjugation of molecules in order to produce compuonds for biological applications. Furthermore, the basic principles to characterize organic molecules by the main spectroscopic techniques (NMR, mass spectroscopy and IR) will be reviewed.
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Results of learning outcomes
At the end of the course, the student may design a protocol for the synthesis of a molecule characterized by the formation of an amido group or an isoster group for examples. The molecule will be also characterized by the student using NMR and/or mass spectroscopy.
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Course delivery
Frontal lessons with the help of powerpoint slides without registration (part of prof. Deagostino), available on the course site
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Learning assessment methods
The exam is oral and will be devoted on a synthesis of an organic molecule and its characterization
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Program
Review of the main organic mechanisms:
electrophilic addition to alkenes;
electrophilic aromatic substitution;
nucleophilic substitution and elimination reactions;
nucleophilic substitution;
nucleophilic addition.
Main protocols to create an amido group from reactive acyl groups.
Main activating agents for the formation of amido group from carboxylic acids.
The Huisgen reaction.
Organometallic mediated reactions: organolithium and Grignard reagents.
Transition metal mediated reactions: Pd(0) mediated reactions.
Characterization of organic molecules: review of the spectroscopic properties of the main organic groups.
Exercises.
Suggested readings and bibliography
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- Book
- Title:
- Organic Chemistry
- Year of publication:
- 2012
- Publisher:
- Oxford Press
- Author:
- J. Clayden, N. Greeves ans S. Warren
- Required:
- No
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- Book
- Title:
- Spectrometric Identification of Organic Compounds ...
- Year of publication:
- 2014
- Publisher:
- John Wiley & Sons
- Author:
- By R. M. Silverstein and G. C. Bassler
- Required:
- No
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