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MEDICINAL CHEMISTRY A
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MEDICINAL CHEMISTRY A
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Academic year 2023/2024
- Course ID
- BIO0232A
- Teacher
- Sonja Visentin (Lecturer)
- Year
- 2nd year
- Teaching period
- Annual
- Type
- Distinctive
- Credits/Recognition
- 6
- Course disciplinary sector (SSD)
- CHIM/08 - pharmaceutical chemistry
- Delivery
- Formal authority
- Language
- English
- Attendance
- Obligatory
- Type of examination
- Oral
- Type of learning unit
- modulo
- Modular course
- MEDICINAL CHEMISTRY (BIO0232)
- Propedeutic for
- no
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Sommario del corso
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Course objectives
This course will begin with an introduction to conventional medicinal chemistry, highlighting the chemical design and application of medicines and why new systems are constantly required. The application of nanomedicine in vitro (e.g. biosensors and diagnostic devices) and in vivo (e.g. drug delivery) will be covered.The course explores how chemists modify a molecule’s structure to design a safe and effective drugs and diagnostic agents. In particular, the principal phases of drug action, the molecular mechanisms of drugs and the drug discovery and development process will be discussed.The module A of the course will provide a comprehensive assessment of the state-of-the-art of biological and biomedical applications of nanomaterials. The course encompasses the unique capabilities of nanoparticles and drug delivery systems or for in vitro detection, in vivo diagnosis, multimodal imaging, chemo-, photo-, gene-, and immunotherapy, theranostics, and their clinical translation- Oggetto:
Results of learning outcomes
KNOWLEDGE AND UNDERSTANDING
- Acquisition of theorietical an applicative skills concerning Medicinal Chemistry principles
APPLYING KNOWLEDGE AND UNDERSTANDING
- Development of the ability to incorporate information from the study of 3D structures of molecules and from information obtained from servers specialised in the prediction of ADME-Tox properties into daily research work
MAKING JUDGEMENTS
- Critical evaluation of the information obtained from 3D and web server abalysis
COMMUNICATION SKILLS
- Acquisition of oral and written communication of results as well as the ability to use graphical language
LEARNING SKILLS
- Acquisition of autonomous learning capacity and self-assessment of its preparation
At the end of the course, students should be able to have learned the various stages that make up the pipeline of drug discovery and understand the chemical and physical properties of the molecules in the pharmaceutical field. Students will build a chemical understanding of the role of drugs, diagnostic agents and nanosystems.
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Program
TOPICS COVERED IN THE COURSE
- Introduction to drug discovery
- ATC clasification of drugs and diagnostics
- Physico-chemical properties of molecules and their influence on the interaction between drugs and their targets
- Principles of Pharmacodynamics and Pharmacokinetics (ADMET-Tox )
- Molecular Descriptors involved in the determination of the ADME profile of potential drugs and diagnostic agents
- Diagnostic agents-types and applications
- The concept of companion diagnostic (CDx)
- Nanotechnology and biomaterials used in medicianl chemistry and diagnostic
The lectures are backed up by a number of case studies and tutorial sessions, which involve the participants in using the concepts discussed.
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Course delivery
48-hours course, splitted in theoritical lessons and practical work
The attendance is optional but strongly recommended
The didactic material will be published on the Moodle platform. The platform course will welcome: lesson materials (video recordings and / or audio presentations); exercises to be carried out online, but also face-to-face; in-depth teaching materials that can be discussed through a forum and / or in the classroom during the lesson-debate
Communication with students takes place through e-mail and requires registration on the Moodle platform
The platform course will welcome: lesson materials (video recordings and / or audio presentations); exercises to be carried out online, but also face-to-face; in-depth teaching materials that can be discussed through a forum and / or in the classroom during the lesson-debate
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Learning assessment methods
Assessments for learning will be ongoing and actionable and will actively involves students in the learning process. It teaches critical thinking skills, problem-solving and encourages students to set achievable goals for themselves and objectively measure their progress using short quizzes, journal entries, student interviews, student reflections and classroom discussions
The final exam will be oral on the program discussed in class
The unit of measure: thirty/30
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Support activities
The lectures is available for students to discuss, repeat explainations and clarify what already explained during the previous lessons at the beginning of each lesson.
The sharing of any doubts is strongly recommended to promote the common growing of all learners
Suggested readings and bibliography
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- Book
- Title:
- Burger's Medicinal Chemistry and Drug Discover
- Year of publication:
- 2020
- Publisher:
- Wiley
- Author:
- Donald Abraham and David Rotella
- ISBN
- Required:
- No
- Enroll
- Open
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